Big-time crime invades a sleepy California community in this drama. Violet (Diane Delano) is an unlikely drug lord who has started dealing amphetamines out of a small town in California, with the help of three legmen who have more in the way of daring than brains. But neither Violet nor her partners in crime imagined they would have to reckon with Rawley Wade (Fred Dryer), the local sheriff who keeps a close eye on illegal activities in the area. As Wade swings into action to put the drug ring behind bars, he discovers a multiple murderer is also on the loose, leaving behind a trail of bodies without rhyme or reason. Highway 395 was the first feature film directed by actor Fred Dryer, best known for his starring role in the television series Hunter.