Rebecca (Moore) is a film actress who is about to make her stage debut at Lincoln Center. Her husband Tom (Duchovny) gave up a lucrative job in advertising to take care of their young daughter. Occasionally Tom and Rebecca have sex; once a year they meet with their therapist (Garry Shandling).
Tom and Rebecca's best friends are her brother Tobey (Crudup), a sportswriter, and his girlfriend Elaine (Gyllenhaal). Elaine, who has been dating Tobey for seven years, has begun to feel the ticking of her biological clock.
Tom and Rebecca each face extramarital temptations. Tom responds to a personal crisis that stems from his decision to choose kids over career by watching pornography and having an affair with a divorced mother from his son's school. Rebecca is pursued on the set by a young costar, Jasper (Justin Bartha), who would like to be able to claim that he's bedded a famous actress.