She's Funny That Way is a screwball comedy featuring the interconnected personal lives of the cast and crew of a Broadway production. When established director Arnold Albertson (Owen Wilson) casts his call girl-turned-actress Isabella “Izzy” Patterson (Imogen Poots) in a new play to star alongside his wife Delta (Kathryn Hahn) and her ex-lover Seth Gilbert (Rhys Ifans), a zany love tangle forms with hilarious twists. Jennifer Aniston plays Izzy’s therapist Jane, who is consumed with her own failing relationship with Arnold’s playwright Joshua Fleet (Will Forte), who is also developing a crush on Izzy.