One Last Thing… is the story of Dylan Jameison (Michael Angarano), a 16 year-old kid from an industrial town in Pennsylvania, who has terminal cancer, and who’s living life as fast as he can. When a charitable organization, “United Wish Givers,” grants Dylan a last wish, he initially chooses to go fishing with his football hero, Jason O’Malley.
But that’s not what he really wants. In a moment of inspiration during the locally televised news conference, Dylan reveals that his true final wish is to spend a weekend with supermodel Nikki Sinclair (Sunny Mabrey).
With the help of his two best friends, Slap (Gideon Glick) and Ricky (Matthew Bush), and star football player Jason O’Malley (Johnny Messner), Dylan spends his last days in Manhattan, trying to fulfill his wish, to the dismay of his single mom, Karen (Cynthia Nixon). In addition to the usual growing pains encountered by a boy his age, Dylan is faced with coming to terms with his imminent departure from this world. His resulting journey is both touching and surprisingly funny.