The movie centers around Aaron Boone (portrayed by Craig Sheffer), a man plagued by dreams of a city called Midian, populated by bizarre creatures and deviants of all types who refer to themselves as the "Nightbreed". Aaron is framed for several murders by his psychopathic therapist, subsequently killed by police and resurrected by the magic of Midian. Boone joins forces with the other monsters to defend themselves from the true monsters of the story: humankind.