When life falls apart, friends keep it together.
They say opposites attract. Milly (Toni Collette) is the woman who has everything: a successful career; a rock-star husband and two beautiful children. Her best friend is Jess (Drew Barrymore), she works in a community garden; lives in a boathouse with her boyfriend Jago and desperately wants a baby.
Friends since childhood Jess and Milly can’t remember a time they didn’t share everything -- secrets, clothes, even boyfriends, their differences are the glue that binds them together. That is until Milly is hit with the life-changing news that she has breast cancer and needs Jess's support more than ever.
As Jess tries to balance her own life as well as being there for Milly it is only a matter of time before the pressure on their bond takes its toll.