Manhattan Romance centers on Danny (Tom O’Brien), a commercial editor and documentary filmmaker, as he attempts to finish his film -- a study on modern relationships -- while navigating the relationships in his own life. Will Danny continue to chase the unattainable Theresa, a free-spirited dancer (Caitlin FitzGerald), or will he finally admit he's in love with his best friend Carla (Katherine Waterston) who is in an unfulfilling relationship with Emmy (Gaby Hoffmann), a political strategist?