As some might have guessed, the film's title is a tribute to James Cameron's Aliens. In the film, audiences hear Bill Paxton yell, "Game over, man! Game over!" It's an awesome tribute, for sure.
Netflix is gambling on the fact that everybody who watched Workaholics will likely show up to catch Game Over, Man!
The trailer looks pretty damn hilarious and, even if the film turns out to be lacking, it should make for an easy viewing on the premium network.