Advertising executive Charles Schine (Clive Owen) is just another Chicago commuter who regularly catches the 8:43am train to work. But the one day he misses his train and meets Lucinda Harris (Jennifer Aniston), his life is changed forever.
Lucinda is charming, beautiful and seductive. Despite the fact that each are married with children, their attraction to one another is magnetic. Lunch dates quickly become cocktails after work, and before long, Charles and Lucinda's infatuation leads them to a hotel room. Their seemingly perfect affair goes terribly awry when LaRoche (Vincent Cassel), a brutal stranger, breaks into their room and holds them at gunpoint. This once illicit liaison turns into a nightmare more dangerous and violent than either could have ever imagined.
Charles' life soon becomes filled with deception, blackmail, violence and crime. Unable to confide in his wife or speak to the police, Charles finds himself trapped in a world he doesn't recognize, with no trace of the life he once knew.
Derailed explores the repercussions of making one terrible mistake that can change someone's life entirely.