The Brothers Solomon tells the hilarious story of Dean and John Solomon (Forte and Arnett), two good-hearted but romantically-challenged brothers. When they find out their dying father's last wish is for a grandchild, the brothers set out to find someone to have a baby with. But after spending their formative years being home schooled by their father in a remote arctic location, their social skills prove to be somewhat lacking and their attempts at fatherhood go hysterically and disastrously wrong.